Systems and methods are provided for regulating pressure, temperature, and/or humidity at a support surface for a user of a wheelchair. Exemplary systems include an adaptable cushion system including at least one cushion having a plurality of pressurized zones, at least one sensor configured to determine pressure at a first pressurized zone, and a controller configured to control an air pump at the first pressurized zone. The air pump is configured to regulate pressure at the first pressurized zone.