JENNINGS, MICHAEL PAUL,DAY, CHRISTOPHER,PATON, ADRIENNE WEBSTER,PATON, JAMES CLELAND
申请号：
CA3044303
公开号：
CA3044303A1
申请日:
2017.11.09
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having a2-3-linked N-glycolylneuraminic acid and glycans having a2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having a2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having a2-3-linked N-glycolylneuraminic acid.
