Hong-Kee Kim,Ho Chul Shin,Yoon-Jung Lee,Ho Soon Lee,Ji-Hye Lee,Seok-chan Kang,Hun-Taek Kim
申请号：
US15105434
公开号：
US09987339B2
申请日:
2014.12.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a pharmaceutical composition with improved stability, comprising a fusion protein comprising Factor VII (FVII) and transferrin, as an active ingredient, wherein the transferrin is linked to the C-terminus of the FVII； and trehalose or glycine as a bulking agent. The composition can store FVII and a variant thereof stably at room temperature for a long period of time. Thus it can be used as a useful therapeutic agent for patients suffering from hemophilia or congenital FVII deficiency.
