PROBLEM TO BE SOLVED: To provide a system capable of controlling the depth of therapy on a tissue surface layer by adjusting the binding rate of a photosensitive substance and a protein such as serum protein by adjusting the temperature of a target tissue for therapy, and varying the reaction efficiency of the photodynamic therapy.SOLUTION: A system for controlling the depth of therapy of the photodynamic therapy by temperature adjustment includes: (i) a light beam irradiation device for irradiating a target tissue for therapy with a light beam and (ii) a cooling device for cooling the target tissue for therapy. The photodynamic therapy is performed on the surface layer of the target tissue for therapy by: having the cooling device cool the surface of the target tissue for therapy in which a photodynamic therapeutic agent is present reducing the binding rate of the photodynamic therapeutic agent present in the surface layer of the target tissue for therapy and serum protein by cooling increasing the ratio of the free photodynamic therapeutic agent on the surface of the target tissue for therapy and having the light beam irradiation device irradiate the target tissue for therapy with the light beam.COPYRIGHT: (C)2014,JPO&INPIT【課題】対象治療組織の温度を調整することで、光感受性物質と血清タンパク質等のタンパク質との結合率を調整し、光線力学的治療の反応効率を変化させ、組織表層での治療深度制御を可能とするシステムを提供する。【解決手段】温度調整により光線力学的治療の治療深度を制御するシステムであって、(i)治療対象組織に光線を照射するための光線照射装置、及び(ii)治療対象組織を冷却するための冷却装置を含み、前記冷却装置に、光線力学的治療薬剤が存在する治療対象組織の表面を冷却させ、冷却により治療対象組織の表層部に存在する光線力学的治療薬剤と血清タンパク質との結合率を低下させ、治療対象組織の表層部の遊離型の光線力学的治療薬剤の比率を高め、前記光線照射装置に、治療対象組織に光線を照射させることにより治療対象組織の表層部において光線力学的治療を行う構成とする。【選択図】なし
