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Aminopyrazine derivatives and corresponding medication
专利权人:
NIPPON SHINYAKU CO.; LTD.
发明人:
FUJIHARA, HIDETAKA,ASAKI, TETSUO,HORI, KATSUTOSHI,NAITO, HARUNA
申请号:
ES10738621
公开号:
ES2453474T3
申请日:
2010.02.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound represented by the general formula [1], or a pharmaceutically acceptable salt thereof, wherein the compound is defined by the following formula 5 (I) or (II), ** Formula ** (Chemical Representation No. 1 ) (Copy figure 1 - 1st formula - from page 8 where, X, represents CH or N; R1, represents a halogen, R2, represents: (1) H, (2) halogen, (3) cyano, (4 ) a group represented by the following general formula (2): (Chemical representation 2) (Copy figure 2 - 2nd formula - on page 8) (where, *, indicates the link position; and RC, RD and RE, they are the same or different and, each of them, represents (a) H or (b) alkyl, optionally substituted by hydroxy or alkoxy, or alternatively, two of the RC, RD and RE30, are taken together, with the Contiguous C, to represent a saturated heterocyclic group containing N, and the other is H, the saturated heterocyclic group being found, optionally substituted by alkyls ulfonil, (5) a group represented by the following general formula (3): (Chemical representation 3) (Copy figure 3 - 1st formula - from page 9) (where, *, has the same meaning as that which has been described above, above; and RF and RG, are the same or different and, each of them, represents (a) H, (b) alkyl, optionally substituted by one or two groups selected from the group consisting of hydroxy, amino, dialkylamino, a cyclic amino group , saturated, alkylcarbonylamino, alkylsulfonylamino, aryl, heteroaryl optionally substituted by alkyl, tetrahydrofuranyl, and carbamoyl, (c) alkylcarbonyl, (d) alkylsufonyl, (e) carbamoyl, or (f) heteroaryl optionally substituted by alkyl, or, in one way alternative, RF and RG, are taken together, with the adjacent N, to represent a saturated, cyclic amino group, which may be optionally substituted with one or two groups selected from the group consisting of (a) halogen, (b) cyano , (c) hydroxy, (d), alkyl optionally substituted by one or two groups selected from the group consisting of hydroxy, alkoxy, amino, alkoxycarbo
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