James C. Barrow,Scott Harrison,James Mulhearn,Cyrille Sur,David L. Williams,Scott Wolkenberg,Eric Hostetler
申请号：
US12995314
公开号：
US08530483B2
申请日:
2009.05.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimers disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimers disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds, or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: X is O or S A and Y independently are N, or CH.
