compound, radiopharmaceutical formulation, pharmaceutical composition, use of the compound, mixing, methods of collecting data for the diagnosis of an amyloid-associated disease or condition, determining the extent of amyloidogenic plaque burden in a tissue and / or body fluid, collecting data to determine a predisposition to an amyloid-associated disease or condition in a patient, to collect data to monitor a minimal residual disease in a patient following treatment with an antibody or vaccine composition, to collect data to predict a patient's ability to react. a patient being treated with a
ANDREAS MUHS,COTINICA HAMEL,HEIKO KROTH,NAMPALLY SREENIVASACHARY,PASCAL BENDERITTER,WOLFGANG FROESTL
申请号：
BR112012026249
公开号：
BR112012026249A2
申请日:
2011.04.15
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
compound, radiopharmaceutical formulation, pharmaceutical composition, use of the compound, mixing, methods of collecting data for the diagnosis of an amyloid-associated disease or condition, determining the extent of amyloidogenic plaque burden in a tissue and / or body fluid, collecting data to determine a predisposition to an amyloid-associated disease or condition in a patient, to collect data to monitor a minimal residual disease in a patient following treatment with an antibody or vaccine composition, to collect data to predict a patient's ability to react. a patient being treated with an antibody or vaccine composition, and, test kit. The present invention relates to novel compounds which may be used in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as alzheimer's disease and diseases or conditions associated with amyloid-like proteins. The compounds of the present invention may also be used in the treatment of eye diseases associated with pathological abnormalities / changes in visual system tissues. The present invention further relates to pharmaceutical compositions comprising these compounds and the use of these compounds for the preparation of medicaments for the treatment or prevention of diseases or conditions associated with amyloid or amyloid-like protein. A method of treating or preventing diseases or conditions associated with amyloid and / or amyloid-like proteins is also disclosed.composto, formulação radiofarmacêutica, composição farmacêutica, uso do composto, mistura, métodos de coletar dados para o diagnóstico de uma doença ou condição associadascom amiloide, de determinar a extensão de carga amiloidogênica de placas em um tecido e/ou um fluido corporal, de coletar dados para determinar uma predisposição a uma doença ou condição associadas com amiloide em um paciente, de coletar dados para monitorar a doença residual mínima em um paciente seguindo o tratamento com um anticorpo ou uma composição de
