Asclepius (Suzhou) Technology Company Group Co.; Ltd.
发明人:
Huashun LI,Baolei WANG,Baoyong REN
申请号：
US16160735
公开号：
US20190231819A1
申请日:
2018.10.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A chimeric antigen receptor (CAR) and a gene encoding the CAR. The CAR comprises an extracellular domain capable of binding to an antigen, a transmembrane domain, and intracellular immune co-stimulatory molecule, wherein the extracellular domain comprises a D2 domain of a Slit2 protein. A chimeric antibody-expressing cell, which introduces a gene encoding the CAR into a cell so as to express the CAR on the surface of the cell. The CAR or CAR-expressing cell can be used as a cell drug for the treatment of tumor diseases. By using the CAR for engineering cells, especially T cells, the engineered T cells can specifically recognize and kill tumors, and have higher tumoricidal activity.
