Ltd.;Asclepius (Suzhou) Technology Company Group Co.
发明人:
Huashun LI,Kunkun HAN,Baolei WANG,Baoyong REN
申请号：
US16893989
公开号：
US20200289573A1
申请日:
2020.06.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides a nucleotide sequence for encoding CAR, a ROBO1 CAR-NK cell of expressing the CAR, and preparation and application thereof. The ROBO1 CAR-NK cell provided by the present invention can specifically kill tumor cells by using ROBO1 antibody for the construction of CAR-NK cells and using ROBO1 molecules as target antigens. It can be used as a therapeutic agent for tumor diseases, for the treatment of tumor with highly expressing of ROBO1, without harmful phenomena such as cytokine release syndrome, thus providing new treatments for the tumors which are ineffective in traditional surgery, chemotherapy and radiotherapy. It has lower toxicity, higher safety and better specific lysis activity compared with ROBO1 CAR-T cell.
