NOUVEAUX DERIVES DE 2,3-DIHYDRO-1H-IMIDAZO{1,2-A}PYRIMIDIN-5-ONE ET DE 1,2,3,4-TETRAHYDROPYRIMIDO{1,2-A}PYRIMIDIN-6-ONE COMPRENANT UNE MORPHOLINE SUBSTITUEE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE
EL-AHMAD, YOUSSEF,FILOCHE-ROMME, BRUNO,LETALLEC, JEAN-PHILIPPE,MARCINIAK, GILBERT,RONAN, BAPTISTE,VIVET, BERTRAND,BROLLO, MAURICE
申请号：
CA2877089
公开号：
CA2877089A1
申请日:
2013.06.21
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to the novel products of formula (I) with p, q = 0, 1 or 2； R1 = phenyl, pyridyl； -(CH2) m -Ra； alkylene； cycloalkyl； heterocycloalkyl； alkyl； -SO2 -Rb； -CO-Re； m = 1 or 2； Ra = aryl, heteroaryl, -CO-cycloalkyl, -CO-heterocycloalkyl, -CO-Rb, -C(Rb)=N-ORc, -CO 2 Rd, -CONRxRy； Rb = alkyl, aryl, heteroaryl； Rc = H, alkyl； Rd = alkyl, cycloalkyl； Re = alkyl, cycloalkyl, aryl, heteroaryl； NRxRy with Rx,Ry = H, alkyl, cycloalkyl, alkoxy, phenyl, or form with N a ring with optionally O, N； R2, R3 = H, alkyl, CF 3, or form with C a ring with optionally O, S and N； R4 = H, F, Cl, CH3 or CN； the morpholine is substituted with Me, and optionally substituted with F, OH； or is (Formula 1a) and the isomer of configuration R,R (Formula 1b) these products being in all the isomer forms and the salts, as medicaments, in particular as anticancer medicaments.
