The present invention relates to Purine Derivatives； compositions comprisingan effective amount of a Purine Derivative； and methods for reducing an animal'score body temperature, protecting an animal's heart against myocardialdamage during cardioplegia； or for treating or preventing a cardiovasculardisease, a neurological disorder, an ophthalmic condition, an ischemic condition,a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administeringan effective amount of a Purine Derivative to an animal in need thereof.
