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ANTIBODIES AGAINST CHIKUNGUNYA VIRUS AND USES THEREOF
专利权人:
发明人:
申请号:
EP14826939.2
公开号:
EP3021868A1
申请日:
2014.07.21
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.
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