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Piperazine compound that has a PGDS inhibitory effect
专利权人:
Taiho Pharmaceutical Co.; Ltd.
发明人:
URADE, Yoshihiro,KITADE, Makoto,SHIGENO, Kazuhiko,YAMANE, Keiko,TANAKA, Katsunao
申请号:
ES11734668
公开号:
ES2601007T3
申请日:
2011.01.19
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Piperazine compound represented by the formula (I) or salt thereof, ** Formula ** in which X represents CH or an N atom; R1 represents C1-6 alkyl; R2 represents C1-6 alkyl which may have 1, 2 or 3 substituents, C2-6 alkenyl which may have 1, 2 or 3 substituents, - (C>; = O) -N (R3) (R4), or - (C>; = O) -OR5, R3 and R4 are the same or different, and each represents hydrogen or C1-6 alkyl which may have 1, 2 or 3 substituents; or R3 and R4 taken together with a nitrogen atom to which R3 and R4 are attached, can form a saturated heterocyclic group; and R5 represents hydrogen or C1-6 alkyl which may have 1, 2 or 3 substituents or aralkyl; wherein the substituents are selected from the group consisting of halogen, hydroxyl, cyano, nitro, alkyl, halogenoalkyl, cycloalkyl, cycloalkyl-alkyl, aralkyl, alkenyl, alkynyl, alkoxy, halogenoalkoxy, cycloalkoxy, cycloalkyl-alkoxy, aralkyloxy, alkylthio, cycloalkyl-alkylthio, amino, mono- or di-alkylamino, cycloalkyl-alkylamino, acyl, acyloxy, oxo, carboxyl, alkoxycarbonyl, aralkyloxycarbonyl, carbamoyl, saturated or unsaturated heterocyclic groups, aromatic hydrocarbon and a saturated heterocycloxy group.Compuesto de piperazina representado por la fórmula (I) o sal del mismo, **Fórmula** en el que X representa CH o un átomo de N; R1 representa alquilo de C1-6; R2 representa alquilo de C1-6 que puede presentar 1, 2 o 3 sustituyentes, alquenilo de C2-6 que puede presentar 1, 2 o 3 sustituyentes, -(C>;=O)-N(R3)(R4), o -(C>;=O)-OR5, R3 y R4 son iguales o diferentes, y cada uno representa hidrógeno o alquilo de C1-6 que puede presentar 1, 2 o 3 sustituyentes; o R3 y R4 tomados junto con un átomo de nitrógeno al que R3 y R4 están unidos, pueden formar un grupo heterocíclico saturado; y R5 representa hidrógeno o a lquilo de C1-6 que puede presentar 1, 2 o 3 sustituyentes o aralquilo; en el que los sustituyentes se seleccionan de entre el grupo que consiste en halógeno, hidroxilo, ciano, nitro, alquilo, halogenoalquilo, cicloalquil
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