REISER, ULRICH,ZAHN, STEPHAN KARL,HERFURTH, LARS,STADTMUELLER, HEINZ,ENGELHARDT, HARALD,STEEGMAIER, MARTIN,BAUM, ANKE,GUERTLER, ULRICH,SCHOOP, ANDREAS,QUANT, JENS,SOLCA, FLAVIO,HAUPTMANN, RUDOLF
申请号：
ES05777896
公开号：
ES2532611T3
申请日:
2005.08.18
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compounds of the general formula (1): ** Formula ** in which W is N or C-R2, X is -NR1a, O or S, Y is CH or N, Z is halogen-C1-3 alkyl, - COH, -C (>； = O) -C1-3alkyl, -C (>； = O) -C2-3alkenyl, -C (>； = O) -C2-3alkynyl, -C (>； = O) -alkyl C1-3 halogen or pseudohalogen； A is chosen from formulas (i), (ii) and (iii): ** Formula ** Q1 means mono- or bicyclic aryl compounds； B1, B2, B3 and B4 mean in each case independently of each other C-RgRh, N-Ri, O or S, but the adjacent B1-B4 does not mean in each case -O-； R1 and R1a mean in each case independently of each other hydrogen or methyl, R2 is a moiety chosen from the group consisting of hydrogen, halogen, -OR4, -C (>； = O) R4, -C (>； = O) NR4R5, -NR4R5, -NR4C (>； = O) R5, -NR4 SO2R5, -N>； = CR4R5, -C>； = NRi, -SR4, -SOR4, -SO2R4, -SO2NR4R5 and pseudohalogen, or an optionally substituted one or more times chosen from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aryl, heterocyclyl and heteroaryl, said or said substituents may be the same or different and chosen from the group consisting of halogen , -NO2, -OR4, -C (>； = O) R4, -C (>； = O) OR4, -C (>； = O) NR4R5, -NR4R5, -NR4C (>； = O) R5, -NR4C (>； = O) OR5, -NR4C (>； = O) NR5R6, -NR4SO2R5, -N>； = CR4R5, -SR4, -SOR4, -SO2R4, -SO2NR4R5, -NR4SO2NR5R6, -OSO2NR5R6 and pseudohalogen； Ra, Rb, Rc, Rd, Re, Rf, Rg and Rh mean in each case independently of each other is a residue chosen from the group consisting of hydrogen, halogen,>； = O, -NO2, -OR4, -C (>； = O) R4, -C (>； = O) OR4, -C (>； = O) NR4R5, -NR4R5, -NR4C (>； = O) R5, -NR4C (>； = O) OR5, -NR4C (>； = O ) NR5R6, -NR4SO2R5, -N>； = CR4R5, -C>； = NRi, -SR4, -SOR4, -SO2R4, -SO2NR4R5, -NR4SO2NR5R6, -OSO2NR5R6 and pseudohalogen； or an optionally substituted moiety once or several times selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, aryl, heterocyclyl and heteroaryl, said or said substituents
