APPLICATION OF METHENAMINE HYDRO SULPHOCYANATE FOR THE PRODUCTION OF DRUGS FOR INFECTIONS CAUSED BY BACTERIA WITH THE NEW DELHI METALLO-BETA-LACTAMASE (NDM-1) GENE
Invention herewith described refers to the application of methenamine hydro sulphocyanate for the production of drugs for infections caused by bacteria with the New Delhi metallo-beta-lactamase (ndm-1) gene. The therapeutic effect is achieved thanks to the circumstances that methenamine hydro sulphocyanate applied as a drug starts "the immunity thunderstorm" &ndash the state of the immunity system which is characterized by an increased intensity of cellular as well as humoral components of the immune response. In such a state, the bacteria with NDM-1 gene partially damaged by synergic action of formaldehyde as the degradation product of methenamine and sulphocyanate ion, become recognizable for the immune system and are more intensively exposed to the specific defense mechanisms, which lead to the desired therapeutic effect.Pronalazak se odnosi na primenu meteiaminhidrorodanida za proizvodnju lekova za infekcije prouzrokovane bakterijama sa Nju Delhi metalo-beta-laktamaza (NDM-1) genom. Terapijski efekat postiže se zahvaljujući okolnosti da metenaminhidrorodanid aplikovan kao lek pokreće «imunitetnu oluju sa grmljavinom» - stanje sistema imuniteta koje karakteriše povećani intenzitet kako ćelijske, tako i humoralne komponente imunog odgovora. U takvom stanju bakterije sa NDM-1 genom, i same delimično oštećene sinergijskim delovanjem formaldehida kao degradacionog produkta metenamina i rodanidnog jona, postaju prepoznatljivije za sistem imuniteta i bivaju intenzivnije izložene specifičnim mehanizmima odbrane koji dovode do željenog terapijskog efekta.
