Vennerstrom, Jonathan L.,Dong, Yuxiang,Charman, Susan A.,Wittlin, Sergio,Chollet, Jacques,Creek, Darren J.,Wang, Xiaofang,Sriraghavan, Kamaraj,Zhou, Lin,Matile, Hugues,Charman, William N.
申请号：
AU2013273836
公开号：
AU2013273836A1
申请日:
2014.01.02
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2013273836A120140313.pdf#####Abstract A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structuraiy simple, easy to synthesize, non-toxic, and potent against malarial Parasites. The compounds of tile invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.
