VENNERSTROM JONATHAN L.,VENNERSTROM Jonathan L.,DONG YUXIANG,DONG Yuxiang,CHARMAN SUSAN A.,CHARMAN Susan A.,WITTLIN SERGIO,WITTLIN Sergio,CHOLLET JACQUES,CHOLLET Jacques,CREEK DARREN J.,CREEK Darren J
申请号：
SI200831204
公开号：
SI2203457T1
申请日:
2008.10.29
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.
