The present invention , as well as various fiber proliferative disease prevention and treatment of liver disease as excellent TGF receptor antagonist activity for example, hepatic fibrosis , liver cirrhosis , pulmonary fibrosis , scleroderma valid , as a preventive and therapeutic agent , such as glomerular fibrosis N - (2,2- disubstituted -2H- chromen-6- yl) - N, N - relates to the medicinal use of disubstituted guanidine derivatives본 발명은 TGFβ 수용체 길항활성이 우수하여 간질환 예방 및 치료제로서는 물론 여러 섬유 증식성 질환 예를 들면 간섬유화, 간경화, 폐섬유증, 피부경화증, 신사구체 섬유증 등의 예방 및 치료제로서 유효한 N-(2,2-이중치환-2H-크로멘-6-일)-N,N-이중치환 구아니딘 유도체의 의약적 용도에 관한 것이다.
