Orthopedic systems and methods for treating an infection are disclosed. An implant can include an exterior shell having an overall shape that defines a shape of the implant and an interior portion. At least a part of the interior portion can be hollow and configured to contain a base material including an antimicrobial or antibiotic. The exterior shell of the implant can include a plurality of perforations formed in at least a part of the exterior shell, and the perforations can release the antimicrobial or antibiotic in the base material from the interior portion of the implant to treat an infection. The base material can include a bone cement, gel, foam or fiber. The implant can be configured for use as a temporary spacer or as a permanent revision implant. After implantation, additional materials can be delivered to the interior portion of the implant and released through the perforations.
