In an acute care setting, rapid onset of the therapeutic effects of medication is highly desirable. The invention provides in-line filters suitable for rapid delivery of a positively charged protein therapeutic via intravenous administration.在急性照護情況中,極度期望快速啟動藥物之治療效果。本發明提供適用於透過靜脈內投與快速傳遞帶正電荷的蛋白質治療藥物之直接插入(in-line)過濾器。