Disclosed is a preparation containing reduced vitamin B2, which can be produced easily and at low cost, can be stably stored and distributed for a long period of time, and can be administered safely. Furthermore, a new use of the unknown reduced vitamin B2 is also provided. In order to solve the above-mentioned problems, the present invention includes reduced water for protecting and restoring vascular endothelial cells caused by mitochondrial activation, comprising hydrogen water and reduced vitamin B2 dissolved in the hydrogen water. Vitamin B2 preparation was used. At the same time, the present invention also acts as an active oxygen scavenger, oxidative stress scavenger, excess cytokine inhibitor, fatigue recovery agent, blood cell count recovery agent, liver / renal disorder recovery agent, cancer disease or dementia prevention or treatment agent. . [Selection] Figure 8【課題】還元型ビタミンＢ２を簡易、低コストで製造し、長期間安定保管、流通でき、さらに安全に投与できる、還元型ビタミンＢ２を含む製剤を提供する。さらに、知られていない還元型ビタミンＢ２の新たな用途も提供する。【解決手段】本発明は、上記課題を解決するため、水素水と、前記水素水に溶解した還元型ビタミンＢ２を含むことを特徴とするミトコンドリア活性化に起因した血管内皮細胞保護回復用還元型ビタミンＢ２製剤とした。同時に本発明は、活性酸素除去剤、酸化ストレス除去剤、過剰サイトカイン抑制剤、疲労回復剤、血球数回復剤、肝・腎障害回復剤、癌疾患或いは認知症の予防又は治療剤としても作用する。【選択図】図８
