Osteoprotegerin derived composition and use thereof

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专利权人:

R-Pharm International; Limited Liability Company

发明人:

Lavrovsky, Yan,Xu, Ting,Repik, Alexey,Guo, Kangping,Samsonov, Mikhail,Ignatiev, Vasily

申请号：

AU2012375257

公开号：

AU2012375257B2

申请日:

2012.03.31

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

A therapeutic composition is described that can be used for treating or prevention of diseases association with bone resorption, particularly of a metastatic carcinoma. In certain aspects, the composition is based on a polypeptide which includes the leading 215 amino acids of the human osteoprotegerin followed by the Fc portion of the human IgGl protein. DNA expression vectors and expression systems for overproducing the polypeptide in mammalian cells are also provided for.

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中国工程科技知识中心

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