A compression garment may generally include an upwardly disposed waist, a seat spaced apart from and connected to a pant front, the seat and the pant front connected to the waist, a single leg portion connected to the seat and the pant front and configured to receive a first leg of a wearer, and an opposing side portion connected to the seat and the pant front and including an aperture opposed to the waist and defined by distal edges of the seat and the pant front, and a compression portion circumferentially around at least a portion of the first leg of the wearer to exert therapeutic pressure on the first leg of the wearer when the compression garment is in use.