The present invention relates to a monodisperse core-shell silica nanoparticle including a core layer based on a hydrophobic organic segment (a2) portion of a copolymer (A) containing an aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and the hydrophobic organic segment (a2) and a shell layer composed of a hybrid based on the aliphatic polyamine chain (a1) portion and silica (B), and also relates to a method for manufacturing such a core-shell silica nanoparticle, a method for manufacturing a hollow silica nanoparticle from such a core-shell silica nanoparticle, and a hollow silica nanoparticle manufactured by this method of manufacture.
