Described herein are integrated programs and systems that manage or treat chronic conditions such as elevated cholesterol or elevated blood pressure and other health conditions. The integrated system may include a combination of: a dietary supplement; behavior change messaging through packaging (including use of unit dose packaging) and/or package inserts; video content available through the web or mobile means; interactive discussions with healthcare providers; and an app or website that supports behavior change as well as tracks ongoing compliance to the dietary supplement and behavior change as well as physiologic endpoints. The integrated system may thus create a routine set of behaviors for the user to help manage or treat various health conditions.