JANDA, KIM D.,JACOB, NICHOLAS T.,LOCKNER, JONATHAN W.
申请号：
CA2944452
公开号：
CA2944452A1
申请日:
2015.03.30
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein. The invention is directed, in various embodiments, to a compound and pharmaceutical composition comprising an effective amount of a compound capable of inducing expression of TRAIL gene in cells capable of expressing the TRAIL gene to produce the cytokine TRAIL.
