ЧЭНЬ Фэн-Цзин (US),КРИЛЛ Стивен Л. (US),ШМЕЙС Рама Абу (US)
申请号：
RU2018142068
公开号：
RU2018142068A
申请日:
2017.05.05
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
The disclosure is directed to fulvestrant formulations including suspensions of fulvestrant particles suitable for injection. The formulations can comprise fulvestrant particles having an LD Dv(10) less than about 3 microns, for example, between about 1 micron to about 3 microns, an LD Dv(50) less than about 35 microns, for example, between about 2 microns and about 35 microns, and an LD Dv(90) less than about 120 microns, for example, between about 4 microns and about 120 microns. The formulations can comprise fulvestrant particles having a CE Dv(90) less than about 200 microns, for example, between about 10 microns and about 200 microns, a CE Dv(50) less than about 60 microns, for example, between about 5 microns and about 60 microns, and a CE Dv(10) less than about 25 microns, for example, between about 1 micron and about 25 microns.
