您的位置：
首页
>
农业专利
>
详情页
Delta-amino-gamma-hydroxy-omega-aryl-alkanesaureamides with enzyme, in particular renin-inhibiting properties.
- 专利权人:
- NOVARTIS AG
- 发明人:
- 申请号：
- DE122011100052
- 公开号：
- DE122011100052I1
- 申请日:
- 2011.09.28
- 申请国别(地区):
- DE
- 年份:
- 2012
- 代理人:
- 摘要：
- delta -Amino- gamma -hydroxy- omega -aryl-alkanoic acid amides (I) and their salts are new: R1 = H； OH； lower alkoxy opt. substd. by lower alkoxy or COOH (opt. esterified or amidated)； or cycloalkoxy； R2 = H； lower alkyl opt. substd. by lower alkoxy, lower alkoxy-lower alkoxy, cycloalkoxy, amino (opt. substd. by lower alkyl, lower alkanoyl and/or lower alkoxycarbonyl), heteroaryl (opt. hydrogenated), lower alkenyloxy or COOH (opt. esterified or amidated)； cycloalkyl； OH； lower alkoxy opt. substd. by hydroxy (opt. lower alkanoylated, halogenated or sulphonylated), amino (opt. substd. by lower alkyl, lower alkanoyl and/or lower alkoxycarbonyl), oxo, cycloalkoxy, lower alkoxy, lower alkenyloxy, lower alkanoyl, lower alkylthio (opt. S-oxidised), lower alkylthio(hydroxy), aryl, heteroaryl (opt. hydrogenated), CN or COOH (opt. esterified or amidated)； cycloalkoxy； lower alkoxy-lower alkenyl； or lower alkoxy-lower alkenyloxy； R3 = lower alkyl opt. substd. by halo, lower alkoxy, cycloalkoxy, OH, lower alkylthio (opt. S-oxidised), heteroarylthio (opt. hydrogenated), heteroaryl (opt. hydrogenated), amino (opt. mono- or di-substd. by lower alkyl or mono-substd. by lower alkanoyl or lower alkanesulphonyl or N,N-disubstd. by lower alkylene, opt. N-alkylated or lower alkanoylated aza-lower alkylene, oxa-lower alkylene or opt. S-oxidised thia-lower alkylene) or COOH (opt. esterified or amidated)； cycloalkyl； aryl； OH； cycloalkoxy； or lower alkoxy opt. substd. by lower alkoxy, cycloalkoxy, OH, aryl, halo, lower alkylthio (opt. S-oxidised), heteroaryl (opt. hydrogenated), heteroarylthio (opt. hydrogenated), amino (opt. mono- or di-substd. by lower alkyl or mono-substd. by lower alkanoyl or lower alkanesulphonyl or N,N-disubstd. by lower alkylene, opt. N-alkylated or lower alkanoylated aza-lower alkylene, oxa-lower alkylene or opt. S-oxidised thia-lower alkylene), CN or COOH (opt. esterified or amidated)； and R4 = H； lower alkyl； OH； lower alkoxy； or cycloalkoxy； or R3 and R4 togethe
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
