COMPOSITION PHARMACEUTIQUE COMPRENANT UN AGENT THERAPEUTIQUE A BASE D'HEMOGLOBINE MODIFIEE POUR UN TRAITEMENT DE CIBLAGE DU CANCER ET IMAGERIE DIAGNOSTIQUE
WONG, BING LOU,WAI, NORMAN FUNG MAN,KWOK, SUI YI,WONG, MAN KIN,MAN, CORNELIA WING YIN
申请号：
CA2911414
公开号：
CA2911414C
申请日:
2014.05.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides apharmaceutical composition containing hemoglobin-based therapeuticagent thr treating cancer. The hemoglobin moiety can targetcancer cells and the therapeutic moiety (i.e. activeagent/therapeutic drug) can kill the cancer cells efficiently.The hemoglobin-based therapeutic agent used in the presentinvention can be used in the treatment of various cancers suchas pancreatic cancer, leukemia, head mid neck cancer,colorectal cancer, lung cancer, breast cancer, liver cancer,nasopharyngeal cancer, esophageal cancer, prostate cancer,stomach cancer and brain cancer. The composition can beused alone or in combination with other therapeutic agent(s)such as chemotherapeutic agent to give a synergistic effect oncancer treatment, inhibiting metastasis and/or reducingrecurrence. The presently claimed hemoglobin-based 5FU-two-dyeconjugate and/or hemoglobin-based 5FU-one-dye conjugatecan also be used in live-cell imaging and diagnostic imaging.
