An instrument holder and grip for detachably connecting to a medical instrument, which has a basic body with a grip section and a connecting section for connecting to the medical instrument. A locking means movable from a release position into a locking position is provided in the connecting section for locking the medical instrument on the connecting section. The instrument holder and grip has lever elements connected together and each mounted pivotably on the basic body. A first element has an actuating lever arm and a second element moves the locking means. The holder permits significantly simplified cleaning and sterilization after use, while continuing to provide a reliable holding effect on the instrument. It is possible to dismantle the instrument holder into a few easily cleaned parts with a few simple actions and without small parts such as connecting pins or similar.