An instrument holder and grip for detachably connecting to a medical, particularly a surgical, instrument, which has a basic body (2) with a grip section (5) and a connecting section (6) for connecting to the medical instrument, wherein a locking means (24) which can be moved from a release position into a locking position is provided in the connecting section (6) for locking a medical instrument (31) to be mounted on the connecting section (6), wherein the instrument holder and grip (1) further has a lever arrangement of lever elements (3, 4) which are connected together and each mounted pivotably on the basic body (2), of which elements a first element (3) has an actuating lever arm (10), a second element (4) moves the locking means (24), particularly formed onto a lever arm (23) of said lever element (4), is improved in that it permits significantly simplified cleaning and sterilization after use, while continuing to provide a reliable holding effect on the instrument, and to this end it is particularly possible to dismantle it into a few easily cleaned parts with a few simple actions and without small parts such as connecting pins or similar.