[Problem] To provide an anti-human TWEAK antibody having excellent activity compared to conventional anti-human TWEAK antibodies and means for preventing or treating various diseases in which TWEAK is involved in disease pathology. [Means for Solution] An anti-human TWEAK antibody comprising a heavy chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 118 of SEQ ID NO:1, the amino acid sequence of amino acid numbers 1 to 125 of SEQ ID NO:5, or the amino acid sequence of amino acid numbers 1 to 121 of the SEQ ID NO:9, and a light chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 108 of SEQ ID NO:3, the amino acid sequence of amino acid numbers 1 to 108 of SEQ ID NO:7, or the amino acid sequence of amino acid numbers 1 to 108 of SEQ ID NO:11, respectively.本發明之課題為提供一種與以往之抗人類TWEAK抗體比較，具有優異活性之抗人類TWEAK抗體，以及使用該抗體來預防或治療，人類TWEAK參與病態形成之各種疾病之手段。作為本發明之解決手段，其係提供一種抗人類TWEAK抗體，其特徵為分別包含：由序列編號1之胺基酸編號1至118之胺基酸序列、由序列編號5之胺基酸編號1至125之胺基酸序列、或由序列編號9之胺基酸編號1至121之胺基酸序列所構成之重鏈可變區、及由序列編號3之胺基酸編號1至108之胺基酸序列、由序列編號7之胺基酸編號1至108之胺基酸序列、或由序列編號11之胺基酸編號1至108之胺基酸序列所構成之輕鏈可變區。
