KIM, YONG IL,金用镒,金用鎰,IM, HO TAEK,林昊泽,林昊澤,ROH, LEEDONG,卢利东,盧利東,YOON, YOUNGSU,尹英洙,PARK, JAE HYUN,朴宰贤,朴宰賢,WOO, JONG SOO,禹锺守,禹鍾守
申请号：
TW105108523
公开号：
TW201639563A
申请日:
2016.03.18
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention provides a pharmaceutical complex formulation comprising a first mixture including amlodipine and chlorthalidone and a second mixture including losartan, which has an improved dissolution and stability. The complex formulation according to the present invention may achieve improved preventive or therapeutic effects for cardiovascular diseases by actuating different mechanism of amlodipine, losartan and chlorthalidone, and exhibits high dissolution rates of amlodipine, losartan and chlorthalidone and improved storage stability, due to the minimized drug interactions, and therefore, it is useful in the fields of pharmaceuticals and medicine.本發明提供一種醫藥複合調配物，其包含包括安洛待平和氯薩利酮的第一混合物以及包括洛沙坦的第二混合物，該醫藥複合調配物具有改良的溶解作用和安定性。依據本發明之複合調配物可透過引動安洛待平、洛沙坦及氯薩利酮不同的機制而達成改良的預防或治療心血管疾病的功效，並且由於最小化的藥物交互作用而展現出安洛待平、洛沙坦及氯薩利酮高度的溶解率以及改良的儲存安定性，且因此在醫藥與醫學領域上是有用的。
