The invention relates to novel compounds, pharmaceutical compositions and use thereof, which inhibit pro-apoptotic caspase-2 to prevent and/or treat diseases and injuries where caspase-2 activity is implicated, in particular neonatal brain ischemia.本發明係有關於新穎化合物、其醫藥組成物及其用途,該等化合物抑制前-細胞凋亡半胱天冬酶-2以預防及/或治療涉及半胱天冬酶-2活性之疾病及損傷,更特別為新生兒腦缺血。