EDWARD B. REILLY,ANDREW C. PHILLIPS,CHUNG HSIEH,LORENZO MING - BENATUIL,FRITZ G. BUCHANAN,JONATHAN A. MEULBROEK,JENNIFER PEREZ
申请号：
ARP150100849
公开号：
AR099812A1
申请日:
2015.03.20
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Antibodies and Antibody Drug Conjugates (ADCS) and anti epidermal growth factor receptor (EGFR), including compositions and Methods for using such Antibodies and ADC.Claim 1: Antibody anti Human epidermal growth factor receptor (anti hegfr), or Antigen binding portions thereof,Wherein: binds to an epitope within the Amino Acid Sequence cgadsyemeedgvrkc (SEQ ID no. 45) or competes with a Second Antibody anti hegfr for Binding to the epidermal growth factor receptor (EGFRvIII) variant III (SEQ ID no. 33) in a competitive binding assay.Where the second anti EGFR Antibody comprises a variable domain of heavy chain is the Amino Acid Sequence that is established in the SEQ ID no. 1 and a light chain variable Domain comprising the Amino Acid Sequence that is established in the SEQ ID no. 5 (b) joins EGFR (1 - 525) (SEQ ID no. 47) with a Dissociation Constant (k\u1d48) of approximately 1 m x 10\u207b\u2076 \u1d52 \u1d50\u1d49\u207f\u1d52\u02e2, \u02e2\u1d49\u1d4d\u00fa\u207f \u02e1\u1d43 \u1d48\u1d49\u1d57\u1d49\u02b3\u1d50\u2071\u207f\u1d43\u1d9c\u2071\u00f3\u207f \u1d50\u1d49\u1d48\u2071\u1d43\u207f\u1d57\u1d49 \u02b3\u1d49\u02e2\u1d52\u207f\u1d43\u207f\u1d9c\u2071\u1d43 \u1d48\u1d49 \u1d56\u02e1\u1d43\u02e2\u1d50\u00f3\u207f \u02e2\u1d58\u1d56\u1d49\u02b3\u1da0\u2071\u1d9c\u2071\u1d43\u02e1 \u02b8 \u1d9c\u207e \u2071\u207f\u02b0\u2071\u1d47\u1d49 \u1d49\u02e1 \u1d9c\u02b3\u1d49\u1d9c\u2071\u1d50\u2071\u1d49\u207f\u1d57\u1d52 \u1d57\u1d58\u1d50\u1d52\u02b3\u1d43\u02e1 \u1d49\u207f \u1d58\u207f \u1d49\u207f\u02e2\u1d43\u02b8\u1d52 \u1d48\u1d49 \u02e3\u1d49\u207f\u1d52\u2071\u207f\u02b2\u1d49\u02b3\u1d57\u1d52 \u2071\u207f \u1d5b\u2071\u1d5b\u1d52 \u1d48\u1d49 \u1d9c\u1d43\u02b3\u1d9c\u2071\u207f\u1d52\u1d50\u1d43 \u1d48\u1d49 \u1d56\u1d58\u02e1\u1d50\u00f3\u207f \u1d43 \u1d9c\u00e9\u02e1\u1d58\u02e1\u1d43\u02e2 \u207f\u1d52 \u1d56\u1d49q\u1d58\u1d49\u00f1\u1d43\u02e2 \u207dnsclc\u207e \u1d9c\u1d52\u207f \u1d58\u207f\u1d43 \u2071\u207f\u02b0\u2071\u1d47\u2071\u1d9c\u2071\u0
