The present invention relates to the method for stabilizing a live cell, bacteria, virus or a virus -like particle (VLP). This is done by growing and multiplying them into modified growth medium containing molecules and/or their mixture which are added to be co- consumed during multiplication of the organism in media or host vector system. Thus produced live cell, bacteria, virus or virus-like particle is internally thermo-stabilized and free from its weakness of thermolability due to insertion of thermo-stabilizing molecules or their mixture. Processing and containerization of these organisms could also be carried out without freezing due to increased thermostability. Such live organisms or virus-like particles could be further formulated into final product with additional thermo- stabilizer and used for human & animals consumption, administration or treatment. The containerization and drying of these products is carried out by Infrared rays or heating by direct/ indirect/convection/conduction method using hot air or single gas or a mixture of gases, using microwave spinning or laser or their combination at temperature between -15 Deg C to 125 deg C without freezing or boiling the liquids under drying. The final live vaccine produced either in dry or liquid state is thermostable and is resistant to high temperature and/or to freezing.
