The deficiency of common cancers immunization therapy is that a kind of specific targets cancer cell is quantitatively enough to significantly reduce in tumor size or carcinous cell number body in effectively amplification T cell. To overcome this limitation, provided herein is nanoparticle coating MHC classifications I and/or II class molecular presentation tumour specific antigens and costimulatory molecules and they be used to extend the horizontal antitumorgienesis of T cells with antigenic specificity and can not achieve technology to current immunotherapy. These include antitumorgienesis T cell antigen specific cytotoxic t lymphocytes, effector T cell, memory T cell, and assistants T cell that be to start and maintaining a large amount of immune responses, precancerous lesion carcinous with metastatic or non-metastatic, in neoplastic cell body. The present invention describes a kind of whole body close to cancer or pre-cancerous cells circulating cells, such as lymthoma together are aimed at, and migrates metastatic cell, solid tumor.
