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FORMULATION DE COMPRIMÉ PHARMACEUTIQUE POUR LE SECTEUR VÉTÉRINAIRE, SON PROCÉDÉ DE PRODUCTION ET D'UTILISATION
专利权人:
Boehringer Ingelheim Vetmedica GmbH
发明人:
申请号:
EP16198169.1
公开号:
EP3167876A1
申请日:
2013.03.14
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The invention is directed to a pharmaceutical tablet formulation for the veterinary medical sector containing an instable ACE inhibitor or a pharmaceutically acceptable salt thereof as a first pharmaceutically active substance, and pimobendan or a pharmaceutically acceptable salt thereof as a second pharmaceutically active substance, comprising granules which contain carrier core particles coated with at least one layer wherein the first pharmaceutically active substance is present, the granules being embedded in a tablet matrix wherein the second pharmaceutically active substance is present. It is provided a "fixed-dose-combination" which allows to ease the treatment and administration of the medication, improves the medication compliance by reducing the pill burden to the animal holder and enables the better observation of and adherence to the therapy by decreasing the number of tablets to be administered. The lower number of tablets leads to a lower treatment failure rate, minimizes dosage mistakes and avoids confusions by false dose intake and slower development of resistance.
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