KUSHNER PETER J,MYLES DAVID C.,HARMON CYRUS L.,GALLAGHER LESLIE CAROL HODGES
申请号：
CL2014001533
公开号：
CL2014001533A1
申请日:
2014.06.11
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Benzopyran compounds with strong anti-estrogenic activity and essentially no estrogenic activity are provided, which are OP-1038, which is 3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol, and OP-1074, which is (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol. OP-1074 is a pure anti-estrogen when tested in the agonist mode and a complete anti-estrogen when tested in the antagonist mode. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.COMPUESTOS DERIVADOS DE 3-FENIL-4-METIL-2-(4-{2-[(3R)-3-METILPIRROLIDIN-1-IL]ETOXI}FENIL)-2H-CROMENO, MODULADORES DEL RECEPTOR DE ESTROGENO； COMPOSICION FARMACEUTICA； UTILES PARA TRATAR UN TRASTORNO MEDIADO POR EL RECEPTOR DE ESTROGENO TAL COMO CANCER DE MAMA, OVARIO, ENDOMETRIO O VAGINA Y TRASTORNO POSTMENOPAUSICO, ENTRE OTROS.
