It also distributed various uses and formulas, Including such modified molecules extended to the C-terminal and / or replaced by amino acids and the components of the production and expression program of these molecules 1: immunoglobulin single variable domain (DAB), including (a) one or more selected modifications C terminal extension, including amino acid extension from amino acid to 5 amino acid； or (b) one or more amino acid structural substitutes, at least one of which is selected from P14a, p41a and l108a substitutes；Compared with the variable domain of a single immunoglobulin (DAB), its binding is reduced to the pre-existing. Claim 37: single immunoglobulin variable domain (DAB) in claim 36, DAB El DAB dom1h-131-206, with only one alachlor growing at terminal C (see Figure 8A: ID No.16),And for the treatment or prevention of at least one disease or disease, selected from the following diseases: arthritis, psychosis, multiple sclerosis, intestinal inflammation (such as Crohn's disease and ulcerative colitis)； or respiratory or pulmonary diseases or diseases, For example: asthma, chronic obstructive pulmonary disease, chronic bronchitis, chronic obstructive bronchitis and emphysema, pulmonary inflammation, chronic obstructive pulmonary disease, asthma, pneumonia, high-sensitivity pneumonia, pneumonia, pneumonia, pneumonia, pneumonia and bronchitis. Cystic fibrosisPulmonary pore disease, primary pulmonary hypertension, pulmonary thrombotic disease, pleura disorder, intermediate disorder, diaphragm disorder, hypothermia, high wind, sleep apnea, acute dyspnea syndrome, mesothelioma, scabies, rejection of transplantation, Host transplant disease, lung cancer, allergic nephritis, allergies, asbestos, allergies, allergies, bronchitis, chronic bronchitis, emphysema, external pneumonia, congenital pulmonary fibrosis, invasive pneumonia, influenza, non pulmonary tuberculosis, pleural effusion, pneumonia, pulmonary inflammation, pneumonia, Pneumonia, pneumococcosisalveol
