A tobacco plant comprising at least one mutation in a HMA gene, wherein the non-mutated HMA gene comprises the nucleotide sequence. of SEQ ID NO: 1 or a homolog sequence, wherein the mutation causes a substitution or a deletion or an insertion of at least one amino acid in the polypeptide encoded by the nucleotide sequence and wherein the mutation reduces the heavy metal uptake by the leaves of the plant by at least 30% in relation to the heavy metal uptake of plants comprising SEQ ID NO:1 or the homolog.
