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QUINAZOLINONE DERIVATIVES AS PARP INHIBITORS
专利权人:
MERK PATENT GMBKH
发明人:
DORSH Diter (DE),ДОРШ Дитер (DE),BUKHSHTALLER Khans-Peter (DE),БУХШТАЛЛЕР Ханс-Петер (DE),DORSH Diter,ДОРШ Дитер,BUKHSHTALLER Khans-Peter,БУХШТАЛЛЕР Ханс-Петер
申请号:
RU2015115576
公开号:
RU0002650107C2
申请日:
2013.08.27
申请国别(地区):
RU
年份:
2018
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to novel quinazolinone derivatives selected from the group of compounds indicated below or pharmaceutically acceptable salts thereof. Compounds possess the properties of an inhibitor of Tankyrase (TANK) and can be used to treat diseases selected from a group consisting of cancer of the head, neck, eye, mouth, throat, esophagus, bronchus, larynx, pharynx, chest, bone, lung, colon, rectum, stomach, prostate, urinary bladder, uterine, cervix, breast, ovaries, testicles or other reproductive organs, skin, thyroid, blood, lymph nodes, kidney, liver, pancreas, brain, central nervous system, solid tumors and malignant transformation of blood.No.Name"A1"6-fluoro-2-[4-(1-hydroxy-1-methylethyl)-phenyl]-3H-quinazolin-4-one"A2"2-[4-(1-hydroxy-1-methylethyl)-phenyl] -8-methoxy-3H-quinazolin-4-one"A3"8-fluoro-2-[4-(1-hydroxy-1-methylethyl)-phenyl]-3H-quinazolin-4-one"A4"5-fluoro-2- [4-(1-hydroxy-1-methylethyl)-phenyl]-3H-quinazolin-4-one"A5"6-chloro-2-[4-(1-hydroxy-1-methylethyl)-phenyl]-3H-quinazolin-4-one"A6"8-chloro-2-[4-(1-hydroxy-1-methylethyl)-phenyl]-3H-quinazolin-4-one"A7"6-fluoro-2-{4-[1- (2-hydroxyethoxy)-1-methylethyl]-phenyl}-3H-quinazolin-4-one"A11"6,8-difluoro-2-[4-(1-hydroxy-1-methylethyl)phenyl]-3H-quinazolin-4-one"A12"5,6-difluoro-2-[4- (1-hydroxy-1-methylethyl)phenyl]-3H-quinazolin-4-one"A13"6-fluoro-2-[5-(1-hydroxy-1-methylethyl)-2-pyridyl]-3H-quinazolin-4-one"A14"2-[4-(1-ethyl-1-hydroxypropyl)phenyl]-6-fluoro-3H-quinazolin-4-one"A16"6-fluoro-2-[4- (1-hydroxycyclopentyl)phenyl]-3H-quinazolin-4-one"A17"6-fluoro-2-[4-(3-hydroxyoxetan-3-yl)phenyl]-3H-quinazolin-4-one"A18"2-[4-[1-(2-aminoethoxy)-1-methylethyl]phenyl]-6-fluoro-3H-quinazolin-4-one"A19"6-fluoro-2-[4-(4-piperidyl)phenyl]-3H-quinazolin-4-one"A21"6-fluoro-2-{4-[1-(2-hydroxyethoxy)-1-methylethyl]-phenyl}-8-methyl-3H-quinazolin-4-one"A23"5-chloro-2-[4-(1-hydroxy-1-methylethyl)-phenyl]-3H-quinazolin-4-one"A24"2-[4-(1-hydroxy-1-methylethyl)-phenyl]-8-methyl-3H-qu
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