Regine Sitruk-Ware,Michael Maria Helmut Schumacher,Roberta Brinton,Martine El-Etr,Abdelmouman Ghoumari,Rachida Guennoun
申请号：
US13725064
公开号：
US09446051B2
申请日:
2012.12.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods for treating neurodegeneration and/or myelination in patients are disclosed comprising treating the patient with a progestin compound which exerts binding to progesterone receptors and elicits progesterone-receptor-induced biological responses without interacting with the androgen receptor and without inducing androgen or glucocorticoid biological responses at a dosage sufficient to prevent or reduce neurodegeneration. The progestin compound preferably comprises 16-methylene-17α-acetoxy-19-norpregn-4-ene-3,20-dione, and the methods include combining the progestin compound with an estrogen compound to provide both contraception and treatment for myelin repair and neurodegeneration, and include effects on stroke and TBI.
