DÉRIVÉ DE N2,N4-BIS(4-(PIPÉRAZINE-1-YL)PHÉNYL)PIRIMIDINE-2,4-DIAMINE OU SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI, ET COMPOSITION CONTENANT CELLE-CI EN TANT QUE SUBSTANCE ACTIVE POUR PRÉVENIR OU TRAITER UN CANCER
LEE, KWANGHO,KIM, HYOUNG RAE,PARK, CHI HOON,LEE, CHONG OCK,LEE, JONG KOOK,JUNG, HEE JUNG,CHO, SUNG YUN,CHAE, CHONG HAK,CHOI, SANG UN,HA, JAE DU
申请号：
EP13827444
公开号：
EP2883875A4
申请日:
2013.05.30
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention relates to a N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and to a composition containing same as an active ingredient for preventing or treating cancer. Since the compound according to the present invention has good effects in inhibiting the activities of anaplastic lymphoma kinase (ALK) and activated Cdc42-associated kinase (ACK1), the compound can have improved therapeutic effects against cancer cells having ALK fusion proteins such as EML4-ALK and NPM-ALK and is expected to be effective in preventing the recurrence of cancer. Therefore, the compound can be effectively used as a composition for preventing or treating cancer.
