CHLORHYDRATE D'AGOMELATINE HYDRATE ET SA PREPARATION

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专利权人:

LES LABORATOIRES SERVIER

发明人:

SHAN, HANBIN,YUAN, ZHEDONG,ZHU, XUEYAN,ZHANG, PENG,PAN, HONGJUAN,YU, XIONG

申请号：

CA2792417

公开号：

CA2792417C

申请日:

2011.03.17

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

An agomelatine hydrochloride hydrate of formula (I), preparation, use, and pharmaceutical composition thereof are provided. Said hydrate obtained through the present method has significant increased solubi1ity than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. Using the present method, high purity can be obtained through a simple process, free of any complicated steps. Wherein X is Cl.

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