DAVIS SAMUEL,MACDONALD LYNN,MURPHY ANDREW J,STEVENS SEAN,MCWHIRTER JOHN,BUCKLER DAVID R
申请号：
NZ63136311
公开号：
NZ631363A
申请日:
2011.02.08
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a B cell obtained from a mouse, wherein said mouse comprises: (a) an insertion at an endogenous mouse kappa immunoglobulin light chain variable region locus of a rearranged human Vkappa1-39/Jkappa sequence, a human Vkappa3-20/Jkappa sequence, or a combination thereof, wherein the human sequence is operably linked to an endogenous mouse kappa constant gene； and (b) an insertion at an endogenous mouse immunoglobulin heavy chain variable region gene locus with a plurality of human immunoglobulin heavy chain variable gene segments, wherein the human immunoglobulin heavy chain variable gene segments are operably linked to an endogenous mouse immunoglobulin heavy chain constant gene, and the human immunoglobulin heavy chain variable gene segments are capable of rearranging and forming a rearranged human/mouse chimeric immunoglobulin heavy chain gene.
