MARSHALL, CHRISTOPHER PATRICK,MCLELLAN, JASON SCOTT,ALFF, PETER JOSEPH,BERTUCCIOLI, CLAUDIO,MARIANI, ROBERTO
申请号：
CA2919353
公开号：
CA2919353A1
申请日:
2014.07.24
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.
