MARSHALL CHRISTOPHER PATRICK,MCLELLAN JASON SCOTT,ALFF PETER JOSEPH,BERTUCCIOLI CLAUDIO,MARIANI ROBERTO
申请号：
IN201627003574
公开号：
IN201627003574A
申请日:
2016.02.02
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
In some embodiments the present invention provides respiratory syncytial virus (RSV) F proteins polypeptides and protein complexes that comprise one or more cross links to stabilize the protein polypeptide or protein complex in its pre fusion conformation. In some embodiments the present invention provides RSV F proteins polypeptides and protein complexes comprising one or more mutations to facilitate such cross linking. In some embodiments the present invention provides compositions comprising such proteins polypeptides or protein complexes including vaccine compositions and methods of making and using the same.
