A delayed release drug formulation for oral administration to deliver a drug to the colon of a subject. The formulation comprises a core comprising and drug and coating for the core. The coating comprises an outer layer and an inner layer. The outer layer comprises a film-forming enteric polymer having a pH threshold at about pH 6 or above and the inner layer comprises a film-forming non-ionic polymer that is soluble in intestinal or gastrointestinal fluid, and a buffer agent in an amount from more than 20 wt % to about 60 wt %, based on the dry weight of the non-ionic polymer.
