Emilie Flora Aurore Delavenne,Daniel Jean Jacques Simon,Morten Otto Alexander Sommer,Rasmus Vendler Toft-Kehler
申请号：
US15662691
公开号：
US09949988B2
申请日:
2017.07.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenes. Gram positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.
